From sequences to contacts to protein folding to structures to networks to genomes to evolution — a circular diagram of protein evolution.

Ovchinnikov Lab · MIT Biology

from sequences to contacts to protein folding to structures to networks to genomes to evolution

News

  • MSA Pairformer
    June 2026 MSA Pairformer is now published in Cell!
    Our compact, MSA-based protein language model that captures the coevolution of interacting proteins — with open-source code and a Colab for quick experimentation.

We build a unified statistical model of protein evolution — integrating coevolution, phylogenetics, structure, and function — and use it to read the notes nature has been taking for billions of years.

Research → A unified model of protein evolution, conformational landscapes, and metagenomic dark matter. Publications → Work on protein language models, structure prediction, design, and structure determination. Tools → Open-source software, including ColabFold and ColabDesign. Join → Openings for undergraduates, graduates, visiting students, and postdocs.