From sequences to contacts to protein folding to structures to networks to genomes to evolution — a circular diagram of protein evolution.

from sequences to contacts to protein folding to structures to networks to genomes to evolution

News

  • CIRPIN
    September 2026 CIRPIN is now published in PNAS!
    A graph neural network that learns circular permutation-invariant structure representations, uncovering putative homologs across the protein universe. Try it directly in your browser at cirpin.solab.org.
  • MSA Pairformer
    June 2026 MSA Pairformer is now published in Cell!
    Our compact, MSA-based protein language model that captures the coevolution of interacting proteins — with open-source code and a Colab for quick experimentation.
  • Jordan Hoff and colleagues in the field
    March 2026 Saving the Oranges
    Lab member Jordan Hoff is featured by the MIT Generative AI Impact Consortium — using generative AI to design protein binders against citrus-greening disease. The project is a lab effort alongside Tomas Lio Grudny, Thomas Fryer, and Simon Kozlov.